原釩酸鈉對(duì)大鼠心臟乳頭肌收縮力的影響.doc
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原釩酸鈉對(duì)大鼠心臟乳頭肌收縮力的影響,本文共5頁(yè) 313字6摘要 目的：初步探討原釩酸鈉對(duì)離體大鼠乳頭肌張力變化的作用及其機(jī)制。方法：①正常wistar大鼠分為正常對(duì)照組，原釩酸鈉組，原釩酸鈉+普奈洛爾組，原釩酸鈉+去甲腎上腺素組，原釩酸鈉+維拉帕米組。②取大鼠乳頭肌放入恒溫平滑肌槽中連于張力換能器，觀察原釩酸鈉等各組對(duì)...
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此文檔由會(huì)員 王亮亮 發(fā)布
原釩酸鈉對(duì)大鼠心臟乳頭肌收縮力的影響
本文共5頁(yè) 313字
6
摘要 目的：初步探討原釩酸鈉對(duì)離體大鼠乳頭肌張力變化的作用及其機(jī)制。
方法：①正常Wistar大鼠分為正常對(duì)照組，原釩酸鈉組，原釩酸鈉+普奈洛爾組，原釩酸鈉+去甲腎上腺素組，原釩酸鈉+維拉帕米組。②取大鼠乳頭肌放入恒溫平滑肌槽中連于張力換能器，觀察原釩酸鈉等各組對(duì)乳頭肌收縮力的影響。結(jié)果：①原釩酸鈉可增強(qiáng)大鼠乳頭肌張力；②去甲腎上腺素可以增加心肌乳頭肌收縮張力。原釩酸鈉對(duì)去甲腎上腺素的這一作用具有協(xié)同作用；③當(dāng)用普奈洛爾阻斷心肌β受體后，原釩酸鈉增加乳頭肌張力的作用消失。結(jié)論：原釩酸鈉可增強(qiáng)大鼠乳頭肌張力，此作用與β受體有關(guān)，但與L-型鈣通道無(wú)關(guān)。
關(guān)鍵詞 原釩酸鈉，乳頭肌
Abstract Objective: primarily investigate the effect and mechanism of sodium orthvanadate to papillary muscle of rat in vitro . Methods: papillary muscle were taken from rat. Then incubated in tynol solution consisting of homeothermia smooth muscle sink,which was hanged under the muscular tension sensor , observing the pharmacology effects the drugs such as sodium orthvanadate ect.to the contractility force of papillary muscle Results:①the contractivity force of papillary muscle can be improved by sodium orthvanadate;②noradrenaline can also increased the contractility force of papillary muscle,which can be symphosized by sodium orthvanadate.;③ The effect of sodium orthvanadate to the tension of papillary muscle disappeared when the β-receptor was blocked by propranolol. Conclusion: The tension of papillary muscle of rat can be improved by sodium orthvanadate. which is related the β-receptor . but has no relation to L-type calcium channel .
Key words sodium orthvanadate ，papillary muscle
參 考 文 獻(xiàn)
[1] Brichard S M, Henquin JC. The role of of vanadium in the management of diabete, Trends Pharmacol sci,1995;16(8):265~270
[2] 杜杰，艾靜，楊寶峰. 原釩酸鈉對(duì)2型糖尿病的降糖作用研究[J]. 中國(guó)藥理學(xué)通報(bào)，2003，19（3）：322-325.
[3] 龍江，何樹(shù)莊，楊寶峰 原釩酸鈉的細(xì)胞毒理學(xué)實(shí)驗(yàn)研究 中國(guó)藥理學(xué)通報(bào) 2003 年 04期
[4] 姚泰 主編 生理學(xué)第五版.北京：人民衛(wèi)生出版社，2002.11 75~76
[5] 楊寶峰 主編 藥理學(xué)第六版.北京：人民衛(wèi)生出版社，2003.8 103~106，194~206
本文共5頁(yè) 313字
6
摘要 目的：初步探討原釩酸鈉對(duì)離體大鼠乳頭肌張力變化的作用及其機(jī)制。
方法：①正常Wistar大鼠分為正常對(duì)照組，原釩酸鈉組，原釩酸鈉+普奈洛爾組，原釩酸鈉+去甲腎上腺素組，原釩酸鈉+維拉帕米組。②取大鼠乳頭肌放入恒溫平滑肌槽中連于張力換能器，觀察原釩酸鈉等各組對(duì)乳頭肌收縮力的影響。結(jié)果：①原釩酸鈉可增強(qiáng)大鼠乳頭肌張力；②去甲腎上腺素可以增加心肌乳頭肌收縮張力。原釩酸鈉對(duì)去甲腎上腺素的這一作用具有協(xié)同作用；③當(dāng)用普奈洛爾阻斷心肌β受體后，原釩酸鈉增加乳頭肌張力的作用消失。結(jié)論：原釩酸鈉可增強(qiáng)大鼠乳頭肌張力，此作用與β受體有關(guān)，但與L-型鈣通道無(wú)關(guān)。
關(guān)鍵詞 原釩酸鈉，乳頭肌
Abstract Objective: primarily investigate the effect and mechanism of sodium orthvanadate to papillary muscle of rat in vitro . Methods: papillary muscle were taken from rat. Then incubated in tynol solution consisting of homeothermia smooth muscle sink,which was hanged under the muscular tension sensor , observing the pharmacology effects the drugs such as sodium orthvanadate ect.to the contractility force of papillary muscle Results:①the contractivity force of papillary muscle can be improved by sodium orthvanadate;②noradrenaline can also increased the contractility force of papillary muscle,which can be symphosized by sodium orthvanadate.;③ The effect of sodium orthvanadate to the tension of papillary muscle disappeared when the β-receptor was blocked by propranolol. Conclusion: The tension of papillary muscle of rat can be improved by sodium orthvanadate. which is related the β-receptor . but has no relation to L-type calcium channel .
Key words sodium orthvanadate ，papillary muscle
參 考 文 獻(xiàn)
[1] Brichard S M, Henquin JC. The role of of vanadium in the management of diabete, Trends Pharmacol sci,1995;16(8):265~270
[2] 杜杰，艾靜，楊寶峰. 原釩酸鈉對(duì)2型糖尿病的降糖作用研究[J]. 中國(guó)藥理學(xué)通報(bào)，2003，19（3）：322-325.
[3] 龍江，何樹(shù)莊，楊寶峰 原釩酸鈉的細(xì)胞毒理學(xué)實(shí)驗(yàn)研究 中國(guó)藥理學(xué)通報(bào) 2003 年 04期
[4] 姚泰 主編 生理學(xué)第五版.北京：人民衛(wèi)生出版社，2002.11 75~76
[5] 楊寶峰 主編 藥理學(xué)第六版.北京：人民衛(wèi)生出版社，2003.8 103~106，194~206
