活化誘導(dǎo)的細(xì)胞死亡與HIV感染

頁(yè)數(shù) 7 字?jǐn)?shù) 4184

摘要：活化誘導(dǎo)的細(xì)胞死亡(AICD)是HIV感染中引起大量T細(xì)胞凋亡的重要機(jī)制之一，因而備受人們的關(guān)注。多種HIV蛋白產(chǎn)物都對(duì)AICD的發(fā)生有不同的作用，而機(jī)體免疫系統(tǒng)的激活狀態(tài)等因素也直接影響AICD的發(fā)生和發(fā)展方向，最終導(dǎo)致患者Th/Ts比例倒置及Kaposi肉瘤發(fā)生等多種臨床特征的出現(xiàn)。IL-16、高效抗逆轉(zhuǎn)錄病毒療法(HAART)等對(duì)AICD的過(guò)程有不同的影響，從而實(shí)現(xiàn)抑制HIV感染和控制病程的效果。

關(guān)鍵詞：AICD,凋亡,HIV,AIDS,激活

Abstract: Activation-induced cell death(AICD) has drawn considerable interest as a key mechanism of T cells apoptosis during HIV infection. Different protein products of HIV show different effects on the process of AICD, and the activation state of the immune system itself may directly decide the initiation and progressing; which altogether lead to various clinical results, such as the reverse of Th/Ts ratio and the occurrence of Kaposi’s sarcoma. Through influencing the process AICD, IL-16、highly active antiretroviral therapy(HAART) may suppress replication and, subsequently, viral spread.
Key words: AICD; apoptosis; HIV; AIDS; activation

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