抗體酶研究進(jìn)展

目錄

前言 3
1 抗體酶研究原理及背景簡(jiǎn)介 3
1.1 抗體酶的發(fā)現(xiàn)及研究思路 3
1.2 抗體酶的原理 4
2 抗體酶的制備方法 4
2.1 誘導(dǎo)法 4
2.2 工程抗體催化法 5
2.3 拷貝法 5
2.4 化學(xué)修飾法 5
3 抗體酶的篩選 6
4 抗體酶的應(yīng)用 6
4.1 抗體酶在醫(yī)藥治療上的應(yīng)用 6
4.1.1 治療可卡因成癮 6
4.1.2 抗腫瘤 6
4.1.3 治療艾滋病 7
4.1.4 治療甲狀腺疾病 7
4.1.5 預(yù)防心腦血管疾病 7
4.1.6 其他 7
4.2 抗體酶在前藥設(shè)計(jì)中的應(yīng)用 8
4.3 抗體酶在有機(jī)合成中的應(yīng)用 8
4.3.1 催化羧酸酯和碳酸酯水解 8
4.3.2 催化消除反應(yīng)及還原反應(yīng) 8
4.3.3 內(nèi)酯化反應(yīng) 9
4.3.4 Claisen重排反應(yīng) 9
4.3.5 催化Diels-Alder 反應(yīng) 9
4.3.6 其它化學(xué)應(yīng)用 9
5 抗體酶存在的問(wèn)題及解決方法 10
6 展望： 10
致謝 11
參考文獻(xiàn)： 12

摘要：抗體酶是一類具有催化活性的免疫球蛋白,它既具有抗體的高效選擇性 ,又能高效催化生物化學(xué)反應(yīng), 抗體酶開(kāi)創(chuàng)了催化劑研究的嶄新領(lǐng)域?？贵w酶的研究深化了對(duì)酶本質(zhì)的認(rèn)識(shí),豐富了酶的種類,是酶學(xué)研究的一大進(jìn)步。本文從抗體酶的作用機(jī)理、設(shè)計(jì)和制備、應(yīng)用和存在的問(wèn)題等多角度進(jìn)行綜述，并對(duì)抗體酶的應(yīng)用前景作了適當(dāng)?shù)恼雇?br /> 關(guān)鍵詞：抗體酶；設(shè)計(jì)制備；作用機(jī)理；研究進(jìn)展

The research progress of abzyme
Major: Biological Engineering   Writer: Wangying  Instructor: liuzhiqiang
Abstract: Abzyme is a kind of immunoglobulin with catalytic activity. It has not only high selectivity as antibodies but also highly catalytic activities as enzymes. It opens a new area of catalyst research. The research on abzyme gained insights into the essence of enzyme, and enriched the kinds of enzyme. It was a big progress for enzymology studies. This paper mainly summarizes on the mechanism of abzyme, the design and manufacture methods, the applications and the existent problems of the abzyme research. Finally, this paper prospects the future applications for abzyme.
Keywords：Abzyme, Design and manufacture methods, Mechanism, Research progress