Purpose: To eva luate quantitative cerebral blood flow (qCBF) with traditional time-based measurements or metrics of cerebral perfusion: time to peak (Tmax) and mean

transit time (MTT) in stroke patients.

Materials and Methods: Nine ischemic stroke patients (four male, five female, 63 6 16 years old) were included in the study which was Health Insurance Portability and

Accountability Act compliant and institutional review board approved. Cerebral perfusion was quantified using the Bookend method. Mean values of qCBF, Tmax, and MTT were determined in regions of interest (ROIs). ROIs were drawn on diffusion weighted images in diffusion positive, critically ischemic (CI), in ipsilateral normal region immediately surrounding the critically ischemic region,the presumed penumbra (PP), and in contralateral diffusion negative control, presumed normal region (PN) of gray and white matter separately (GM and WM).

目的：采用傳統(tǒng)的基于時(shí)間的腦灌注測(cè)量或度量方法，定量評(píng)估腦血流量：腦卒中病人腦血流量的達(dá)峰的時(shí)間(Tmax)和平均通過時(shí)間(MTT)。

材料和方法：經(jīng)過了機(jī)構(gòu)審查委員會(huì)批準(zhǔn)并遵循醫(yī)療保險(xiǎn)便利及責(zé)任法案，本研究納入9名缺血性腦卒中病人（4名男性，5名女性，年齡為63±16）。使用書夾法對(duì)腦灌注進(jìn)行定量分析。測(cè)定了感興趣區(qū)域（ROIs）的腦血流量均值、最大峰值時(shí)間和平均通過時(shí)間。感興趣區(qū)域包括彌散陽(yáng)性區(qū)以及嚴(yán)重缺血區(qū)域的彌散加權(quán)成像，迅速波