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疏血通對(duì)大鼠腦出血后腦水腫的影響.doc

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疏血通對(duì)大鼠腦出血后腦水腫的影響,本文共計(jì)33頁(yè),16130字;摘要目的探討應(yīng)用疏血通進(jìn)行抗凝血酶治療對(duì)大鼠腦出血后早期腦水腫的影響及初步評(píng)估治療的安全性。方法將Ⅳ型膠原酶定向注入大鼠左側(cè)的尾殼核制作大鼠腦出血模型,并在注入膠原酶后4小時(shí)通過(guò)大鼠尾靜脈注射疏血通進(jìn)行抗凝血酶治療,48小時(shí)后觀察大鼠的腦組織的含水量、k+、...
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疏血通對(duì)大鼠腦出血后腦水腫的影響

本文共計(jì)33頁(yè),16130字;

摘要
目的
探討應(yīng)用疏血通進(jìn)行抗凝血酶治療對(duì)大鼠腦出血后早期腦水腫的影響及初步評(píng)估治療的安全性。
方法
將Ⅳ型膠原酶定向注入大鼠左側(cè)的尾殼核制作大鼠腦出血模型,并在注入膠原酶后4小時(shí)通過(guò)大鼠尾靜脈注射疏血通進(jìn)行抗凝血酶治療,48小時(shí)后觀察大鼠的腦組織的含水量、K+、Na+的含量以及血腫體積來(lái)評(píng)價(jià)治療對(duì)腦出血后腦水腫的影響及治療的安全性。
關(guān)鍵詞
腦出血,腦水腫,疏血通
Abstract
Objective
To observe the effect and safety of anti-thrombin treatment on ICH-induced early edema with Shuxuetong.
Method
We made the experimental intracerebral hemorrhage model in which Stereotaxic infusion of collagenase induced intracerebral hemorrhage. We infused Shuxuetong through tail venous 4 hours after infusion of collagenase. After 48 hours we observed the effect of Shuxuetong on brain water content, sodium and potassium content, and volume of hematoma.
目錄
前言……………………………………………………1
摘要……………………………………………………2
正文……………………………………………………4
綜述……………………………………………………19
M G……………………………………………………27
致謝……………………………………………………31

部分參考文獻(xiàn)
1. Lee KR, Betz AL, Kim S, et al. The role of the coagulation cascade in brain edema formation after intracerebral hemorrhage. Acta Neurochir (Wien). 1996; 138(4): 396-401.
2. Xi G, Wagner KR, Keep RF, et al. Role of blood clot formation on early edema development after experimental intracerebral hemorrhage. Stroke. 1998 Dec; 29(12): 2580-2586.
3. Xi G, Hua Y, Bhasin RR, et al. Mechanisms of edema formation after intracerebral hemorrhage: effects of extravasated red blood cells on blood flow and blood-brain barrier integrity. Stroke. 2001, 32: 2932-2938.
4. Xi G, Keep RF, Hoff JT. Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats. J Neurosurg. 1998, 89: 991-996.